Scientists have examined the genetic history of a large group of cheetahs and have found that
there was a significant decrease in the genetic diversity of the cheetah species about 10,000 years
ago. Scientists found that, even in unrelated groups of cheetahs, individual cheetahs had 99% of
the same alleles. By comparison, in a genetically diverse population, even closely related
individuals contain only 80% of the same alleles. Genetic diversity is important to the survival of a
species, and scientists worry that a disease that cheetahs are not resistant to could decimate the
population.
Major histocompatibility complex (MC) genes are used by the body to identify self from non-self
and direct the immune system to attack non-self particles. Invading bacteria and viruses do not
contain the same MHC genes and therefore are attacked by the immune system. Within a
population, a high diversity of MHC genes protects the population from attack by disease. In a
highly diverse population, it is likely that at least some individuals will contain an allele that
identifies a new disease as non-self and can direct the immune system to destroy it.
In 1985, research by Stephen O'Brien reported that skin grafts from cheetahs in a zoo in Oregon
were accepted by cheetahs in Africa. Skin grafts, like other organ donations, must be between
Individuals that have the same MHC factors. If any of the genetic factors are different, then the
immune system of the individual receiving the organ will identify the organ as non-self and the
body will attack the donated organ as if it were a foreign organism such as a virus or bacterium.
The conclusion from
O'Brien's research was that cheetah MHC genes are as alike as those of identical twins.
More recent research by Simone Sommer took a much more comprehensive approach to
examining the genes of a large sample of wild cheetahs. Sommer's research determined how
many alleles are present on two different types of MHC genes in approximately 150 cheetahs.
Sommer was able to show that the variation in some MHC genes was higher than previously
thought. The variation in MHC genes in cheetahs is still smaller than that for other big cat species
but appears to be sufficient to allow the populations to identify a wide variety of foreign particles.
Sommer's research concludes that cheetahs have sufficient genetic diversity to respond to common diseases, but may still be at risk of new diseases. Which statement from the passage supports this conclusion?
- A. Major histocompatibility complex (MHC) genes are used by the body to identify self from non-self...
- B. The variation in MHC genes in cheetahs is still smaller than that for other big cat species but appears to be sufficient...
- C. If any of the genetic factors are different, then the immune system of the individual...
- D. Sommer's research determined how many alleles are present on two different types of MHC genes...
Correct Answer & Rationale
Correct Answer: B
Option B directly supports Sommer's conclusion by highlighting that the variation in MHC genes among cheetahs, while less than in other big cats, is adequate for their immune response to common diseases. This indicates sufficient genetic diversity for disease management, aligning with the research's findings. Option A discusses the function of MHC genes but does not address their variation in cheetahs, making it less relevant. Option C mentions genetic factors affecting immune response but lacks specific information about cheetah genetic diversity. Option D focuses on the number of alleles without linking it to the implications for disease response, thus failing to support the conclusion effectively.
Option B directly supports Sommer's conclusion by highlighting that the variation in MHC genes among cheetahs, while less than in other big cats, is adequate for their immune response to common diseases. This indicates sufficient genetic diversity for disease management, aligning with the research's findings. Option A discusses the function of MHC genes but does not address their variation in cheetahs, making it less relevant. Option C mentions genetic factors affecting immune response but lacks specific information about cheetah genetic diversity. Option D focuses on the number of alleles without linking it to the implications for disease response, thus failing to support the conclusion effectively.
Other Related Questions
How do the results of Bateson's experiment affect the interpretation of Mendel's experimental results?
- A. Bateson's experimental results show that Mendel's conclusions were incorrect.
- B. Bateson's experimental results show that Mendel's conclusions were incomplete.
- C. Bateson's experiments resulted in different ratios of traits in the offspring, confirming Mendel's conclusion.
- D. Bateson's experiments studied different traits than Mendel's so Bateson's results could not challenge or support Mendel's conclusions.
Correct Answer & Rationale
Correct Answer: B
Bateson's experimental results highlight that Mendel's conclusions, while groundbreaking, did not encompass all genetic variations and interactions. Mendel's work focused primarily on simple traits, but Bateson demonstrated that there are complexities in inheritance that Mendel did not address, indicating that his findings were incomplete. Option A is incorrect as Bateson did not disprove Mendel but rather expanded on his work. Option C misinterprets Bateson's findings; while they may align with Mendel's, they also reveal additional complexities rather than merely confirming his conclusions. Option D is misleading; although Bateson studied different traits, the implications of his findings still relate to Mendel’s conclusions, thereby challenging and enriching our understanding of genetics.
Bateson's experimental results highlight that Mendel's conclusions, while groundbreaking, did not encompass all genetic variations and interactions. Mendel's work focused primarily on simple traits, but Bateson demonstrated that there are complexities in inheritance that Mendel did not address, indicating that his findings were incomplete. Option A is incorrect as Bateson did not disprove Mendel but rather expanded on his work. Option C misinterprets Bateson's findings; while they may align with Mendel's, they also reveal additional complexities rather than merely confirming his conclusions. Option D is misleading; although Bateson studied different traits, the implications of his findings still relate to Mendel’s conclusions, thereby challenging and enriching our understanding of genetics.
Which instruction would be most appropriate for step 2 of the procedure?
- A. Provide both group A and group B participants with a daily magnesium supplement.
- B. Provide group A participants with a daily magnesium supplement and provide group B participants with a daily supplement that contains only inactive ingredients.
- C. Provide group A participants with a high-magnesium supplement and group B participants with a low-magnesium supplement...
- D. Provide both group A and group B participants with guidelines about which foods they should consume.
Correct Answer & Rationale
Correct Answer: B
Option B is the most appropriate instruction for step 2 as it establishes a clear experimental control. By giving group A a magnesium supplement and group B an inactive placebo, it allows for a direct comparison of the effects of magnesium on the participants. Option A is incorrect because it does not create a control group; both groups would receive magnesium, making it impossible to determine its specific effects. Option C is flawed as it introduces an additional variable by varying the magnesium levels between groups, complicating the results. Option D fails to provide a direct intervention, which is essential for assessing the impact of magnesium supplementation.
Option B is the most appropriate instruction for step 2 as it establishes a clear experimental control. By giving group A a magnesium supplement and group B an inactive placebo, it allows for a direct comparison of the effects of magnesium on the participants. Option A is incorrect because it does not create a control group; both groups would receive magnesium, making it impossible to determine its specific effects. Option C is flawed as it introduces an additional variable by varying the magnesium levels between groups, complicating the results. Option D fails to provide a direct intervention, which is essential for assessing the impact of magnesium supplementation.
Placing solid ammonium nitrate, NH4NO3, in a container of water causes an endothermic reaction. The result is ammonium hydroxide, NH4OH, and nitric acid, HNO3. Which diagram shows the correct equation for the reaction?
- A. NH4OH + HNO3 → NH4NO3 + H2O + energy
- B. NH4NO3 + H2O + energy → NH4OH + HNO3
- C. NH4NO3 + H2O → NH4OH + HNO3 + energy
- D. NH4OH + HNO3 + energy → NH4NO3 + H2O
Correct Answer & Rationale
Correct Answer: B
The reaction involving solid ammonium nitrate and water is endothermic, meaning it absorbs energy. Option B accurately reflects this by showing ammonium nitrate and water reacting to form ammonium hydroxide and nitric acid while requiring energy input, consistent with the endothermic nature of the process. Option A incorrectly suggests that energy is released, which contradicts the reaction's endothermic characteristic. Option C also misrepresents the energy aspect, implying that energy is produced, which is not the case. Option D similarly indicates that energy is released, misaligning with the reaction's true nature.
The reaction involving solid ammonium nitrate and water is endothermic, meaning it absorbs energy. Option B accurately reflects this by showing ammonium nitrate and water reacting to form ammonium hydroxide and nitric acid while requiring energy input, consistent with the endothermic nature of the process. Option A incorrectly suggests that energy is released, which contradicts the reaction's endothermic characteristic. Option C also misrepresents the energy aspect, implying that energy is produced, which is not the case. Option D similarly indicates that energy is released, misaligning with the reaction's true nature.
Which statement correctly summarizes this information?
- A. Hemochromatosis is a dominant genetic disease caused by a single mutation.
- B. Hemochromatosis is a recessive genetic disease, but is caused by a lack of iron.
- C. Hemochromatosis is a recessive genetic disease, but the expression differs in individuals.
- D. Hemochromatosis is a dominant genetic disease that can be caused by several different alleles.
Correct Answer & Rationale
Correct Answer: C
Hemochromatosis is indeed a recessive genetic disorder, meaning that two copies of the mutated gene are typically required for the disease to manifest. Option A incorrectly categorizes it as a dominant disease, which does not align with its genetic inheritance pattern. Option B misstates the condition, as hemochromatosis is characterized by iron overload, not a deficiency. Option D also misrepresents the disease; while there are different alleles involved, hemochromatosis is primarily recessive, not dominant, making option C the most accurate summary of the information.
Hemochromatosis is indeed a recessive genetic disorder, meaning that two copies of the mutated gene are typically required for the disease to manifest. Option A incorrectly categorizes it as a dominant disease, which does not align with its genetic inheritance pattern. Option B misstates the condition, as hemochromatosis is characterized by iron overload, not a deficiency. Option D also misrepresents the disease; while there are different alleles involved, hemochromatosis is primarily recessive, not dominant, making option C the most accurate summary of the information.